For more than 25 years, the US Institute for Healthcare Improvement (IHI) has used improvement science to advance and sustain better outcomes in health and health care across the world. They bring awareness of safety and quality to millions, accelerate learning and the systematic improvement of care, develop solutions to previously intractable challenges, and mobilise health systems, communities, regions, and nations to reduce harm and deaths. They work in collaboration with the growing IHI community to spark bold, inventive ways to improve the health of individuals and populations. They generate optimism, harvest fresh ideas, and support anyone, anywhere who wants to profoundly change health and health care for the better.