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Found 999 results
  1. News Article
    Nurse leaders are lobbying government to update "fundamentally flawed" guidance on personal protective equipment. The Royal College of Nursing says the existing recommendations are based on out-of-date evidence. One nurse told the BBC she had not been allowed to wear a higher-grade mask, despite having to go into the homes of patients with Covid. The nurse, who wishes to remain anonymous, wanted to use what's known as an FFP3 mask that filters out infectious aerosols. But she says her employers insisted on following national guidance, that most health staff should wear thinner surgical masks, instead. This comes at a time of mounting concern among many healthcare organisations that personal protective equipment (PPE) is inadequate. A new report for the Royal College of Nursing (RCN) criticises the official guidelines for PPE as "fundamentally flawed" because they're based on out-of-date evidence. It says that the risk of infection by aerosols is not given enough emphasis and that key research papers highlighting the possibility of airborne transmission have not been considered. The RCN's report concludes that key research papers on aerosols appear to have been ignored and that the terms used to search for new papers were likely to be "biased against" those on airborne transmission. The lead author of the study, Prof Dinah Gould, says she is "very disappointed" at the review for not taking into account the latest science. "A year into the pandemic, the review needs replacing. It needs updating and we should be able to offer healthcare workers and patients better than what we're offering them now." Read full story Source: BBC News, 7 March 2021
  2. News Article
    Scientists have warned that emerging data on Long Covid in children should not be ignored given the lack of a vaccine for this age group, but cautioned that the evidence describing these enduring symptoms in the young is so far uncertain. Recently published data from the Office for National Statistics (ONS) suggests that 13% of under 11s and about 15% of 12 to 16 year olds reported at least one symptom five weeks after a confirmed COVID-19 infection. Although children are relatively less likely to become infected, transmit the virus and be hospitalised, the key question is whether even mild or asymptomatic infection can lead to Long Covid in children, said Danny Altmann, professor of immunology at Imperial College London. “The answer is that it certainly can, and the Long Covid support groups contain a not insignificant number of children and teens,” Altmann said. Frances Simpson, a lecturer in psychology at Coventry University and co-founder of the Long Covid Kids group, said she was very worried about the emerging data on Long Covid in children. “We just think that there should be a much more cautious and curious approach to long Covid rather than a kind of a sweeping generalisation that children are OK, and that we should just let them all go back to school without any measures being put in place.” One issue, she said, is the sizeable gap between acute infection and Long Covid kicking off. Some children are initially asymptomatic or have mild symptoms but then it might be six or seven weeks before they start experiencing long Covid symptoms, which can range from standard post-viral fatigue and headaches to neuropsychiatric symptoms such as seizures, or even skin lesions." At the moment there is no consensus on the scale and impact of long Covid in adults, but emerging data is concerning. For children, the data is even more scarce. Recent reports from hospitals in Sweden and Italy have generated concern, but this data is not from national trials – they are single-centre studies – and include relatively small patient numbers, said Sir Terence Stephenson, a Nuffield professor of child health at University College London. Stephenson was awarded £1.36m last month to lead a study investigating Long Covid in 11- to 17-year-olds. “I don’t have a scientific view on what long Covid is in young people is – because frankly, we don’t know,” he said. Preliminary results are expected in three months. Read full story Source: The Guardian, 2 March 2021
  3. News Article
    A new COVID vaccine efficacy study from Israel has concluded that Pfizer/BioNTech's jab is up to 85% effective after the first dose. The research, conducted by the Sheba Medical Centre, the country's largest hospital, has been published in the Lancet medical journal. The hospital assessed the effectiveness of the first dose of the Pfizer/BioNTech vaccine among 7,000 of its healthcare employees. The workers each received their first dose in January and the research team observed an 85% reduction of clinical (symptomatic) COVID-19 between 15 and 28 days after the jab. But critically, they also observed efficacy in asymptomatic patients. The study found that all infections, including asymptomatic, were reduced by 75% after the first dose. Professor Eyal Leshem, an infectious disease expert and director of Sheba's Institute for Travel and Tropical Medicine, told Sky News: "This is first real-world evidence of effectiveness that shows up after the first dose of the vaccine." Read full story Source: Sky News, 19 February 2021
  4. News Article
    At home early abortions pose no greater risk and allow women to have the procedure much earlier on in their pregnancy, research has found. The findings have sparked calls from leading healthcare providers for the option, which was rolled out in the wake of lockdown measures last spring, to be made permanent. Researchers, who conducted the UK’s largest study into abortions, discovered there were no cases of significant infection which necessitated the woman to go to hospital or have major surgery. The study, conducted by the British Pregnancy Advisory Service and MSI Reproductive Choices, drew attention to the fact that despite misinformation to the contrary, not one individual died from having an at home early abortion. Eight in ten women said at home abortions were their preferred choice and they would opt for it in the future, while waiting times from when the woman has her consultation to treatment improved from 11 days to 7 days. Dr Jonathan Lord, medical director for MSI Reproductive Choices UK, said: “Being able to access abortion care earlier in pregnancy has also reduced the low complication rate even further.” Dr Lord added: “Telemedicine has provided a lifeline for vulnerable women and girls who cannot attend consultations in-person. We have seen a major increase in safeguarding disclosures, including from survivors of domestic and sexual violence, as they can talk more freely about distressing and intimate details from the privacy of their own home at the beginning of the Covid emergency." Read full story Source: The Independent, 19 February 2021
  5. News Article
    A trial of an experimental coronavirus vaccine detected the most sobering signal yet that people who have recovered from infections are not completely protected against a variant that originated in South Africa and is spreading rapidly, preliminary data presented this week suggests. The finding, though far from conclusive, has potential implications for how the pandemic will be brought under control, underscoring the critical role of vaccination, including for people who have already recovered from infections. Reaching herd immunity — the threshold when enough people achieve protection and the virus can’t seed new outbreaks — will depend on a mass vaccination campaign that has been constrained by limited supply. Anthony S. Fauci, director of the National Institute of Allergy and Infectious Diseases, noted that it appears a vaccine is better than natural infection in protecting people, calling it “a big, strong plug to get vaccinated” and a reality check for people who may have assumed that because they have already been infected, they are immune. Read full story Source: The Washington Post, 6 February 2021
  6. News Article
    Thousands of women living in the UK suffering from an aggressive type of breast cancer could be helped by a newly identified drug, according to a study. The research, carried out by The Institute of Cancer Research, found medicine presently used to help other breast cancers that have spread to another area of the body, could actually be utilised to help around a fifth of women who have triple negative breast cancer. Around 55,000 women are diagnosed with breast cancer in Britain each year, with approximately one in five of these being triple negative. Younger women and black women are more likely to develop this form of breast cancer which is generally more aggressive. Researchers’ realisation the drug palbociclib could be used far more widely than previously thought could “provide a much-needed targeted treatment” for those who are at higher risk of witnessing their cancer spread more quickly, becoming incurable and often unresponsive to conventional chemotherapy. Dr Simon Vincent, of Breast Cancer Now, a leading charity which funded the study, said: “It’s hugely exciting that this research has uncovered a new possible use for palbociclib as a targeted treatment for some women living with triple negative breast cancer." Read full story Source: The Independent, 28 January 2021
  7. News Article
    New research has suggested there are specific molecular responses found in some COVID-19 patients which could be used to determine their likelihood of suffering from severe or long Covid symptoms, very early on following infection. Researchers, supported by NIHR Cambridge Biomedical Research Centre, had set out to increase our understanding of the relationship between the immune response and COVID-19 symptoms by recruiting individuals who tested positive for the virus into a cohort of the NIHR BioResource. Studying 207 people who had tested positive for COVID-19 over a three-month period, taking blood samples and measuring their symptoms, then comparing to samples taken from 45 healthy people, the researchers were able to uncover a number of interesting new findings. Their research showed that people with either an asymptomatic or mild case of COVID-19 mounted a robust immune response to the virus soon after getting infected. These individuals produced a greater number of T cells, B cells and antibodies than patients with more severe COVID-19 infections and within the first week of infection - after which these numbers rapidly returned to normal. The study also showed there was no evidence in these patients of widespread inflammation which can lead to damage in multiple organs. In contrast, people with severe COVID-19 who required hospitalisation showed an impaired immune response, which led to a delayed and weakened attempt to fight the virus and widespread inflammation from the time of symptom onset. In patients requiring admission to hospital, the early immune response was delayed, and profound abnormalities were present in a number of immune cells. Read full story Source: NHE, 22 January 2021
  8. News Article
    A new state of the art institute for antimicrobial research is to open at Oxford University thanks to a £100 million donation from Ineos. Ineos, one of the world’s largest manufacturing companies, and the University of Oxford are launching a new world-leading institute to combat the growing global issue of antimicrobial resistance (AMR), which currently causes an estimated 1.5 million excess deaths each year- and could cause over 10m deaths per year by 2050. Predicted to also create a global economic toll of $100 trillion by mid-century, it is arguably the greatest economic and healthcare challenge facing the world post-Covid. It is bacterial resistance, caused by overuse and misuse of antibiotics, which arguably poses the broadest threat to global populations. The world is fast running out of effective antibiotics as bacteria evolve to develop resistance to our taken-for-granted treatments. Without urgent collaborative action to prevent common microbes becoming multi-drug resistant (commonly known as ‘superbugs’), we could return to a world where taken-for-granted treatments such as chemotherapy and hip replacements could become too risky, childbirth becomes extremely dangerous, and even a basic scratch could kill. The rapid progression of antibacterial resistance is a natural process, exacerbated by significant overuse and misuse of antibiotics not only in human populations but especially in agriculture. Meanwhile, the field of new drug discovery has attracted insufficient scientific interest and funding in recent decades meaning no new antibiotics have been successfully developed since the 1980s. Alongside its drug discovery work, the IOI intends to partner with other global leaders in the field of Antimicrobial Resistance (AMR) to raise awareness and promote responsible use of antimicrobial drugs. The academic team will contribute to research on the type and extent of drug resistant microbes across the world, and critically, will seek to attract and train the brightest minds in science to tackle this ‘silent pandemic’. Read full story Source: University of Oxford, 19 January 2021
  9. News Article
    COVID-19 patients in England's busiest intensive care units (ICUs) in 2020 were 20% more likely to die, University College London research has found. The increased risk was equivalent to gaining a decade in age. By the end of 2020, one in three hospital trusts in England was running at higher than 85% capacity. Eleven trusts were completely full on 30 December, and the total number of people in intensive care with Covid has continued to rise since then. The link between full ICUs and higher death rates was already known, but this study is the first to measure its effect during the pandemic. Tighter lockdown restrictions are needed to prevent hospitals from being overwhelmed, says study author Dr Bilal Mateen. Researchers looked at more than 4,000 patients who were admitted to intensive care units in 114 hospital trusts in England between April and June last year. They found the risk of dying was almost a fifth higher in ICUs where more than 85% of beds were occupied, than in those running at between 45% and 85% capacity. That meant a 60-year-old being treated in one of these units had the same risk of dying as a 70-year-old on a quieter ward. The Royal College of Emergency Medicine sets 85% as the maximum safe level of bed occupancy. However, the team found there was no tipping point after which deaths rose - instead, survival rates fell consistently as bed-occupancy increased. This suggests "a lot of harm is occurring before you get to 85%". Read full story Source: BBC News, 14 January 2021
  10. News Article
    A large-scale trial of a new treatment it is hoped will help stop COVID-19 patients from developing severe illness has begun in the UK. The first patient received the treatment at Hull Royal Infirmary on Tuesday afternoon. It involves inhaling a protein called interferon beta which the body produces when it gets a viral infection. The hope is it will stimulate the immune system, priming cells to be ready to fight off viruses. Early findings suggested the treatment cut the odds of a COVID-19 patient in hospital developing severe disease - such as requiring ventilation - by almost 80%. It was developed at Southampton University Hospital and is being produced by the Southampton-based biotech company, Synairgen. Read full story Source: BBC News, 13 January 2021
  11. News Article
    A coronavirus patient's gut bacteria may influence the length and severity of their infection and their immune response to it, a new study suggests. A team of researchers at The Chinese University of Hong Kong examined whether the variety and quantity of microbiome played a role in COVID-19 infections. Researchers found that patients with COVID-19 were depleted in gut bacteria known to modify a person's immune response, and that this depletion appeared to persist 30 days after the virus had gone. Gut bacteria — or gut microbiome — help to digest food. But research increasingly shows that gut bacteria also affect our health. The study, published in the journal Gut, found that the composition of gut microbiome had changed in COVID-19 patients, compared to those who did not have the infection. It said that gut microbiome could be involved in the "magnitude of COVID-19 severity possibly via modulating host immune responses". Read full story Source: The Independent, 12 January 2021
  12. News Article
    The latest edition of the Wolters Kluwer Journal of Patient Safety has just been published. Original studies include: Is There a Mismatch Between the Perspectives of Patients and Regulators on Healthcare Quality? A Survey Study The Ideal Hospital Discharge Summary: A Survey of U.S. Physicians Impact of an Original Methodological Tool on the Identification of Corrective and Preventive Actions After Root Cause Analysis of Adverse Events in Health Care Facilities: Results of a Randomized Controlled Trial Detach Yourself: The Positive Effect of Psychological Detachment on Patient Safety in Long-Term Care Patient Safety Activity Under the Social Insurance Medical Fee Schedule in Japan: An Overview of the 2010 Nationwide Survey Sustaining Teamwork Behaviors Through Reinforcement of TeamSTEPPS Principles Prescribing Errors With Low-Molecular-Weight Heparins Development and Psychometric Evaluation of the Speaking Up About Patient Safety Questionnaire Descriptive Analysis of Patient Misidentification From Incident Report System Data in a Large Academic Hospital Federation Medication Errors at Hospital Admission and Discharge: Risk Factors and Impact of Medication Reconciliation Process to Improve Healthcare Reducing and Sustaining Duplicate Medical Record Creation by Usability Testing and System Redesign Full articles are payalled but the abstracts may be viewed free of charge. Access the Journal here
  13. News Article
    The country’s largest clinical study is being launched in Greater Manchester to investigate the best gap between first and second Covid-19 vaccine doses for pregnant women. Led by St George’s, University of London, the Preg-CoV study will provide vital clinical trial data on the immune response to vaccination at different dose intervals – either four to six weeks or eight to 12 weeks. This data will help determine the best dosage interval and reveal more about how the vaccine works to protect pregnant mothers and their babies against Covid-19. Pregnant women are more likely to develop severe Covid-19 or die from the disease but are excluded from clinical trials with new vaccines. This means there are currently very limited clinical trial data on the immune response and side effects caused by the vaccines for these women. Read the full story here Source: National Health Executive
  14. News Article
    New commentary interprets the data published in the national patient safety incident reports (NaPSIR) for England in September 2021. Access the commentary here (PDF, 20 pages)
  15. News Article
    Changes to periods and unexpected vaginal bleeding after having a Covid vaccine should be investigated to reassure women, says a leading immunologist specialising in fertility. Writing in the BMJ, Dr Victoria Male, from Imperial College London, said the body's immune response was the likely cause, not something in the vaccines. There is no evidence they have any impact on pregnancy or fertility. The UK's regulator has received more than 30,000 reports of period problems. These include heavier than usual periods, delayed periods and unexpected bleeding after all three Covid vaccines, out of more than 47 million doses given to women in the UK to date. After reviewing the reports, the Medicines and Healthcare products Regulatory Agency (MHRA) says it "does not support a link" between Covid vaccines and the symptoms. However, writing in an opinion piece in the BMJ, Dr Male says "robust research" into reports of period problems would help to counter misinformation around the vaccines. "Vaccine hesitancy among young women is largely driven by false claims that COVID-19 vaccines could harm their chances of future pregnancy. Failing to thoroughly investigate reports of menstrual changes after vaccination is likely to fuel these fears." "If a link between vaccination and menstrual changes is confirmed, this information will allow people to plan for potentially altered cycles," she said. Read full story Source: BBC News, 16 September 2021
  16. News Article
    UCLH has been awarded £6.8m to conduct what has been regarded as the largest Long Covid clinical study and will focus on understanding the condition, how to diagnose it, manage it and improve the recovery process. The research will be a collaborative effort and will include 30 researchers, health professionals, patients and industry partners from more than 30 organisations and the project will be known as TIMULATE-ICP (Symptoms, Trajectory, Inequalities and Management: Understanding Long-Covid to Address and Transform Existing Integrated Care Pathways). Read full story. Source: National Health Executive, 19 July 2021
  17. News Article
    A new study has been published focusing on surgical innovation and how it could be made safer. The research set out to develop a 'core outcome set', an agreed minimum set of outcomes to measure and report for safe surgical techniques in all audits, research, and clinical practice. The study, co-led by Dr Kerry Avery, a Senior Lecturer at the University of Bristol and NIHR Bristol Biomedical Research Centre (BRC) has said "It may surprise many people to learn that surgical procedures haven’t traditionally been subject to the kind of regulation we see in other areas of medicine. But to ensure safety and improve efficiency, a core outcome set is an important step". Read full story. Source: University of Bristol, 13 July 2021
  18. News Article
    Research by the BBC finds thousands of people with disabilities had been forgotten about during the pandemic, revealing most participants experienced worsening of their disability and many said their vital appointments had been cancelled. The research found some reported attempting suicide due to the sudden changes, being isolated or not being able to access their care or support networks. Scope, one of the UK's biggest disabilities charities have said the research conducted by the BBC confirms the government failed to support people with disabilities during the pandemic. Read full story. Source: BBC, 30 June 2021
  19. News Article
    To lower hospital readmission rates for patients with chronic obstructive pulmonary disease (COPD), UB pharmacy researcher David Jacobs has received a $962,000 award from the US National Heart, Lung, and Blood Institute to develop a real-time readmission risk-prediction algorithm. Through a five-year Mentored Patient-Oriented Research Career Development Award, Jacobs will combine social information with rich clinical data to build predictive models that will be integrated into patient-centric interventions and tested in clinical practices. If successful, the research will help clinicians provide individualized treatment at the transition from hospital to home for COPD patients, who experience high rates of early hospital readmission, says Jacobs. “Each year, 7.8 million hospital-discharged patients are readmitted, costing the United States $17 billion,” says Jacobs, assistant professor of pharmacy practice, School of Pharmacy and Pharmaceutical Sciences. “High readmission rates are linked to several quality-of-care and patient-safety factors, such as medication-related problems, inaccurate information transfer, and lack of care coordination with primary care,” he says. “Our focus will be to apply innovative informatic techniques to the development of risk prediction models for hospital readmissions that ultimately personalizes care management interventions.” Read full story Source: UBNow, 21 May 2021
  20. News Article
    COVID-19 vaccines tend to alleviate the symptoms of long Covid, according to a large survey of more than 800 people that suggests mRNA vaccines, in particular, are beneficial. Although COVID-19 was initially understood to be a largely respiratory illness from which most would recover within a few weeks, as the pandemic wore on increasing numbers of people reported experiencing symptoms for months on end. There is no consensus definition of the condition of these people who have symptoms ranging from chronic fatigue to organ damage, let alone a standardised treatment plan. As vaccines hit the mainstream, concerns arose that vaccination could precipitate relapses or a worsening of symptoms. But conversely, anecdotal reports suggested that vaccines helped some people with long Covid. The analysis, which is yet to be peer reviewed, was conducted on the basis of a survey of 812 people (mostly white, female participants) with long Covid in advocacy groups in the UK and internationally who were contacted via social media. The participants (a small proportion of whom also said they had ME/CFS) were asked to wait at least a week after their first dose to avoid their responses conflating with side-effects of the vaccine. In general, those who received mRNA vaccines (Pfizer/BioNTech or Moderna) reported more improvements in symptoms, compared with those who got an adenovirus vaccine (Oxford/AstraZeneca). In particular, those who received the Moderna vaccine were more likely to see improvements in symptoms such as fatigue, brain fog and muscle pain, and less likely to report a deterioration, the analysis found. Read full story Source: The Guardian, 18 May 2021
  21. Event
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    Join the National Academies of Sciences, Engineering, and Medicine’s Committee on Improving the Representation of Women and Underrepresented Minorities in Clinical Trials and Research as it discusses its newly released report Improving Representation in Clinical Trials and Research: Building Research Equity for Women and Underrepresented Groups. This new report makes a compelling case for why we need more equitable participation in clinical trials and clinical research, including an economic analysis on the cost of health disparities in the United States. It provides a review of the barriers to having more equitable participation in clinical trials, describes strategies to overcome those barriers, and provides actionable recommendations to drive lasting change on this issue. The webinar will take place at 11:00-13:00 EST (16:00-18:00 GMT+1) Register for the webinar
  22. Event
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    This Westminster Forum is an opportunity to discuss the implementation of the NHS Long COVID plan for 2021/22, how to utilise funding set out for the expansion of services and management of Long COVID within primary care, the future outlook for Long COVID research, and the impact of new NIHR-funded projects. Key areas for discussion include: delivery of the Long COVID Plan and the utilisation of allocated funding priority areas for research to further improve understanding of Long COVID and the effectiveness of services developed for the condition care pathways within local health systems - leadership, implementation and commissioning, service development, rehabilitation, the impact of health inequalities, and integrating care Long COVID assessment clinics: - assessing progress and what more is needed to improve accessibility and support referrals from primary care - priorities for the development of services for children support for the health workforce - training and education priorities and sharing best practice in Long COVID care utilising data - scaling up its use and improving understanding of Long COVID and its prevalence involving patients - the development of Long COVID services, driving awareness of expanded online support, and improving equal accessibility to information. Agenda Register
  23. Event
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    THIS Space, is now open for registration. It will be held online on 24 and 25 November 2021. Aiming to promote interdisciplinary and intergenerational exchange to build the field of healthcare improvement studies, THIS Space is open to all and free to attend for those in the UK and internationally. The event will create space for interaction, networking, and sharing – you can find out more about the programme here. THIS Space aims to: provide a focus for knowledge sharing in healthcare improvement stimulate innovation and fresh thinking help researchers to develop the habits, knowledge, skills, and experiences to support their professional growth connect colleagues from across different disciplines who share a common goal be a means of accelerating the development of the field of the study of healthcare. Register
  24. Event
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    While the pandemic didn’t cause all the shifts happening in healthcare, it had a major hand in accelerating and shaping the changes that will alter the healthcare landscape far into the future. Join Fierce Healthcare as we examine the tectonic transformation across healthcare. We’ll explore changing consumer expectations in access to care, the moves by major tech players and providers to reach their customers and strategies for actually paying for everything. Register
  25. Event
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    Perspectum has launched the first study to map how COVID-19 impacts the health of multiple organs and identify at-risk features for the virus, with detailed cross-sectional imaging and genetic studies. This study is on the National Institute for Health Research (NIHR) Portfolio. Join COVERSCAN for the next live Q&A webinar. Any questions you'd like answered, send to: Perspectum.Communications@perspectum.com Register for study participant Q&A
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